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Conclusión
 




Se ha comprobado científicamente que en el 

consumo de las xantonas contenidas en el pericarpio 

de la fruta del magostan tiene actividades anti- 

tumorigénicas y antiinflamatorias y actúa entonces 

como un coadyuvante para distintos tratamientos 

de diversos padecimientos patofisiológicos.





 




 


*Isela Camacho Velasco, Licenciada en Química en la Facultad 

de Estudios Superiores Cuautitlán 2010, Orgullosamente 
mexicana, desarrollo su propia marca, Alesi® - Productos 

orgánicos elaborados con extractos naturales. Isela enfoca sus 
actividades al cuidado del medio ambiente en el desarrollo de 

productos que generen calidad de vida.

e-mail: a_alesi@hotmail.com




FUENTES DE CONSULTA
 


(1) Obolskiy D., Pischel I., Siriwatanametanon N., Heinrich M. (2009) Garcinia mangostana L.: A phytochemical and pharmacological review. 
Phytother.;23:1047–1065


(2) Walker E.B. (2007) HPLC analysis of selected xanthones in mangosteen fruit. J. 30:1229–1234.

(3) Pedraza-Chaverri, J., Cárdenas-Rodríguez, N., Orozco-Ibarra, M., Pérez-Rojas, J. (2008). Medicinal properties of mangosteen (Garcinia man- 

gostana). Food and Chemical Toxicology, Volume 46(10):3227-3239

(4) Bumrungpert A., Kalpravidh R. W., Chuang, C., Overman A., Martinez K., Kennedy A., McIntosh M., (2010) Xanthones from Mangosteen In- 
hibit Inflammation in Human Macrophages and in Human Adipocytes Exposed to Macrophage-Conditioned Media, The Journal of Nutrition, 

140(4):842-847.

(5) Syamsudin L., Faizatun L., Rahayu L. (2009). HPLC analysis and pharmacokinetic study of mangostin after orally administration in rats. T. 
Pharm. Res.; 2: 43–49.


(6) Chitchumroonchokchai C., Thomas-Ahner J. M., Li J., Riedl K.M., Nontakham J., Suksumrarn S., Clinton S.K., Kinghorn A.D., Failla M.L. (2013).

Anti-tumorigenicity of dietary-mangostin in an HT-29 colon cell xenograft model and the tissue distribution of xanthones and their phase 
II metabolites. Mol. Nutr. Food Res.;57: 203–211.


(7) Ramaiya A., Li G., Petiwala S.M., (2012) Johnson J.J. Single dose oral pharmacokinetic profile of-mangostin in mice. Curr. Drug Targets. 13: 
1698–1704.


(8) Pinto, M.M., Sousa M. E., Nascimento M. S. J., (2005). Xanthone Derivatives: New Insights in Biological Activities. Current Medicinal Che- 
mistry, 12(21): 2517.2538.

(9) Bumrungpert A., Kalpravidh R.W., Suksamrarn S., Chaivisuthangkura A., Chitchumroonchokchai C., Failla M.L. (2009) Bioaccessibility, 

biotransformation, and transport of-mangostin from Garcinia mangostana (mangosteen) using simulated digestion and Caco-2 human 
intestinal cells. Mol. Nutr. Food Res.; 53 (Suppl. 1): 54–61

(10) Bumrungpert A., Kalpravidh R.W., Chitchumroonchokchai C., Chuang C.C., West T., Kennedy A., McIntosh M. (2009). Xanthones from man- 

gosteen prevent lipopolysaccharide-mediated inflammation and insulin resistance in primary cultures of human adipocytes. J. Nutr.;139: 
1185–1191

(11) Nakagawa Y., Iinuma M., Naoe T., Nozawa Y., Akao Y. (2007). Characterized mechanism of-mangostin-induced cell death: Caspase-inde- 

pendent apoptosis with release of endonuclease-G from mitochondria and increased miR-143 expression in human colorectal cancer DLD-1 
cells. Bioorg. Med. Chem.;15: 5620–5628


(12) Hung S., Shen K., Wu C., Liu C., Shih Y. (2009). -Mangostin suppresses PC-3 human prostate carcinoma cell metastasis by inhibiting ma- 
trix metalloproteinase-2/9 and urokinase-plasminogen expression through the JNK signaling pathway. J. Agric. Food Chem.; 57: 1291–1298.




  
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